Th2 Cytokines Inhibit Lymphangiogenesis
Identifieur interne : 001771 ( Main/Exploration ); précédent : 001770; suivant : 001772Th2 Cytokines Inhibit Lymphangiogenesis
Auteurs : Ira L. Savetsky ; Swapna Ghanta ; Jason C. Gardenier ; Jeremy S. Torrisi ; Gabriela D. García Nores ; Geoffrey E. Hespe ; Matthew D. Nitti ; Raghu P. Kataru ; Babak J. MehraraSource :
- PLoS ONE [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Cellules endothéliales (cytologie), Cellules endothéliales (immunologie), Interleukine-13 (immunologie), Interleukine-4 (immunologie), Lymphangiogenèse (immunologie), Lymphocytes auxiliaires Th2 (cytologie), Lymphocytes auxiliaires Th2 (immunologie), Mouvement cellulaire (immunologie), Mâle, Prolifération cellulaire, Souris, Survie cellulaire (immunologie).
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , immunology : Interleukin-13, Interleukin-4.
- cytology : Endothelial Cells, Th2 Cells.
- immunology : Cell Movement, Cell Survival, Endothelial Cells, Lymphangiogenesis, Th2 Cells.
- Animals, Cell Proliferation, Male, Mice.
Abstract
Lymphangiogenesis is the process by which new lymphatic vessels grow in response to pathologic stimuli such as wound healing, inflammation, and tumor metastasis. It is well-recognized that growth factors and cytokines regulate lymphangiogenesis by promoting or inhibiting lymphatic endothelial cell (LEC) proliferation, migration and differentiation. Our group has shown that the expression of T-helper 2 (Th2) cytokines is markedly increased in lymphedema, and that these cytokines inhibit lymphatic function by increasing fibrosis and promoting changes in the extracellular matrix. However, while the evidence supporting a role for T cells and Th2 cytokines as negative regulators of lymphatic function is clear, the direct effects of Th2 cytokines on isolated LECs remains poorly understood. Using
Url:
DOI: 10.1371/journal.pone.0126908
PubMed: 26039103
PubMed Central: 4454507
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000426
- to stream Pmc, to step Curation: 000426
- to stream Pmc, to step Checkpoint: 000E29
- to stream PubMed, to step Corpus: 000E56
- to stream PubMed, to step Curation: 000E56
- to stream PubMed, to step Checkpoint: 000E56
- to stream Ncbi, to step Merge: 007453
- to stream Ncbi, to step Curation: 007453
- to stream Ncbi, to step Checkpoint: 007453
- to stream Main, to step Merge: 001773
- to stream Main, to step Curation: 001771
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Th2 Cytokines Inhibit Lymphangiogenesis</title><author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L." last="Savetsky">Ira L. Savetsky</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C." last="Gardenier">Jason C. Gardenier</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S." last="Torrisi">Jeremy S. Torrisi</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Garcia Nores, Gabriela D" sort="Garcia Nores, Gabriela D" uniqKey="Garcia Nores G" first="Gabriela D." last="García Nores">Gabriela D. García Nores</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Hespe, Geoffrey E" sort="Hespe, Geoffrey E" uniqKey="Hespe G" first="Geoffrey E." last="Hespe">Geoffrey E. Hespe</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Nitti, Matthew D" sort="Nitti, Matthew D" uniqKey="Nitti M" first="Matthew D." last="Nitti">Matthew D. Nitti</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Kataru, Raghu P" sort="Kataru, Raghu P" uniqKey="Kataru R" first="Raghu P." last="Kataru">Raghu P. Kataru</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26039103</idno><idno type="pmc">4454507</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4454507</idno><idno type="RBID">PMC:4454507</idno><idno type="doi">10.1371/journal.pone.0126908</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000426</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000426</idno><idno type="wicri:Area/Pmc/Curation">000426</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000426</idno><idno type="wicri:Area/Pmc/Checkpoint">000E29</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E29</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000E56</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000E56</idno><idno type="wicri:Area/PubMed/Curation">000E56</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000E56</idno><idno type="wicri:Area/PubMed/Checkpoint">000E56</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000E56</idno><idno type="wicri:Area/Ncbi/Merge">007453</idno><idno type="wicri:Area/Ncbi/Curation">007453</idno><idno type="wicri:Area/Ncbi/Checkpoint">007453</idno><idno type="wicri:Area/Main/Merge">001773</idno><idno type="wicri:Area/Main/Curation">001771</idno><idno type="wicri:Area/Main/Exploration">001771</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Th2 Cytokines Inhibit Lymphangiogenesis</title><author><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L." last="Savetsky">Ira L. Savetsky</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C." last="Gardenier">Jason C. Gardenier</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S." last="Torrisi">Jeremy S. Torrisi</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Garcia Nores, Gabriela D" sort="Garcia Nores, Gabriela D" uniqKey="Garcia Nores G" first="Gabriela D." last="García Nores">Gabriela D. García Nores</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Hespe, Geoffrey E" sort="Hespe, Geoffrey E" uniqKey="Hespe G" first="Geoffrey E." last="Hespe">Geoffrey E. Hespe</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Nitti, Matthew D" sort="Nitti, Matthew D" uniqKey="Nitti M" first="Matthew D." last="Nitti">Matthew D. Nitti</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Kataru, Raghu P" sort="Kataru, Raghu P" uniqKey="Kataru R" first="Raghu P." last="Kataru">Raghu P. Kataru</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author><author><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name><affiliation><nlm:aff id="aff001"></nlm:aff></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Movement (immunology)</term><term>Cell Proliferation</term><term>Cell Survival (immunology)</term><term>Endothelial Cells (cytology)</term><term>Endothelial Cells (immunology)</term><term>Interleukin-13 (immunology)</term><term>Interleukin-4 (immunology)</term><term>Lymphangiogenesis (immunology)</term><term>Male</term><term>Mice</term><term>Th2 Cells (cytology)</term><term>Th2 Cells (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules endothéliales (cytologie)</term><term>Cellules endothéliales (immunologie)</term><term>Interleukine-13 (immunologie)</term><term>Interleukine-4 (immunologie)</term><term>Lymphangiogenèse (immunologie)</term><term>Lymphocytes auxiliaires Th2 (cytologie)</term><term>Lymphocytes auxiliaires Th2 (immunologie)</term><term>Mouvement cellulaire (immunologie)</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Souris</term><term>Survie cellulaire (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Interleukin-13</term><term>Interleukin-4</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Lymphocytes auxiliaires Th2</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Endothelial Cells</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules endothéliales</term><term>Interleukine-13</term><term>Interleukine-4</term><term>Lymphangiogenèse</term><term>Lymphocytes auxiliaires Th2</term><term>Mouvement cellulaire</term><term>Survie cellulaire</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cell Movement</term><term>Cell Survival</term><term>Endothelial Cells</term><term>Lymphangiogenesis</term><term>Th2 Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Proliferation</term><term>Male</term><term>Mice</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Mâle</term><term>Prolifération cellulaire</term><term>Souris</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Lymphangiogenesis is the process by which new lymphatic vessels grow in response to pathologic stimuli such as wound healing, inflammation, and tumor metastasis. It is well-recognized that growth factors and cytokines regulate lymphangiogenesis by promoting or inhibiting lymphatic endothelial cell (LEC) proliferation, migration and differentiation. Our group has shown that the expression of T-helper 2 (Th2) cytokines is markedly increased in lymphedema, and that these cytokines inhibit lymphatic function by increasing fibrosis and promoting changes in the extracellular matrix. However, while the evidence supporting a role for T cells and Th2 cytokines as negative regulators of lymphatic function is clear, the direct effects of Th2 cytokines on isolated LECs remains poorly understood. Using <italic>in vitro</italic> and <italic>in vivo</italic> studies, we show that physiologic doses of interleukin-4 (IL-4) and interleukin-13 (IL-13) have profound anti-lymphangiogenic effects and potently impair LEC survival, proliferation, migration, and tubule formation. Inhibition of these cytokines with targeted monoclonal antibodies in the cornea suture model specifically increases inflammatory lymphangiogenesis without concomitant changes in angiogenesis. These findings suggest that manipulation of anti-lymphangiogenic pathways may represent a novel and potent means of improving lymphangiogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Bjorndahl, Ma" uniqKey="Bjorndahl M">MA Bjorndahl</name></author><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Burton, Jb" uniqKey="Burton J">JB Burton</name></author><author><name sortKey="Brakenhielm, E" uniqKey="Brakenhielm E">E Brakenhielm</name></author><author><name sortKey="Religa, P" uniqKey="Religa P">P Religa</name></author><author><name sortKey="Galter, D" uniqKey="Galter D">D Galter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cursiefen, C" uniqKey="Cursiefen C">C Cursiefen</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Borges, Lp" uniqKey="Borges L">LP Borges</name></author><author><name sortKey="Jackson, D" uniqKey="Jackson D">D Jackson</name></author><author><name sortKey="Cao, J" uniqKey="Cao J">J Cao</name></author><author><name sortKey="Radziejewski, C" uniqKey="Radziejewski C">C Radziejewski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Haiko, P" uniqKey="Haiko P">P Haiko</name></author><author><name sortKey="Sainio, K" uniqKey="Sainio K">K Sainio</name></author><author><name sortKey="Partanen, J" uniqKey="Partanen J">J Partanen</name></author><author><name sortKey="Taipale, J" uniqKey="Taipale J">J Taipale</name></author><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karpanen, T" uniqKey="Karpanen T">T Karpanen</name></author><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alitalo, K" uniqKey="Alitalo K">K Alitalo</name></author><author><name sortKey="Tammela, T" uniqKey="Tammela T">T Tammela</name></author><author><name sortKey="Petrova, Tv" uniqKey="Petrova T">TV Petrova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zampell, Jc" uniqKey="Zampell J">JC Zampell</name></author><author><name sortKey="Avraham, T" uniqKey="Avraham T">T Avraham</name></author><author><name sortKey="Yoder, N" uniqKey="Yoder N">N Yoder</name></author><author><name sortKey="Fort, N" uniqKey="Fort N">N Fort</name></author><author><name sortKey="Yan, A" uniqKey="Yan A">A Yan</name></author><author><name sortKey="Weitman, Es" uniqKey="Weitman E">ES Weitman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oka, M" uniqKey="Oka M">M Oka</name></author><author><name sortKey="Iwata, C" uniqKey="Iwata C">C Iwata</name></author><author><name sortKey="Suzuki, Hi" uniqKey="Suzuki H">HI Suzuki</name></author><author><name sortKey="Kiyono, K" uniqKey="Kiyono K">K Kiyono</name></author><author><name sortKey="Morishita, Y" uniqKey="Morishita Y">Y Morishita</name></author><author><name sortKey="Watabe, T" uniqKey="Watabe T">T Watabe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clavin, Nw" uniqKey="Clavin N">NW Clavin</name></author><author><name sortKey="Avraham, T" uniqKey="Avraham T">T Avraham</name></author><author><name sortKey="Fernandez, J" uniqKey="Fernandez J">J Fernandez</name></author><author><name sortKey="Daluvoy, Sv" uniqKey="Daluvoy S">SV Daluvoy</name></author><author><name sortKey="Soares, Ma" uniqKey="Soares M">MA Soares</name></author><author><name sortKey="Chaudhry, A" uniqKey="Chaudhry A">A Chaudhry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avraham, T" uniqKey="Avraham T">T Avraham</name></author><author><name sortKey="Daluvoy, S" uniqKey="Daluvoy S">S Daluvoy</name></author><author><name sortKey="Zampell, J" uniqKey="Zampell J">J Zampell</name></author><author><name sortKey="Yan, A" uniqKey="Yan A">A Yan</name></author><author><name sortKey="Haviv, Ys" uniqKey="Haviv Y">YS Haviv</name></author><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shao, X" uniqKey="Shao X">X Shao</name></author><author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kataru, Rp" uniqKey="Kataru R">RP Kataru</name></author><author><name sortKey="Kim, H" uniqKey="Kim H">H Kim</name></author><author><name sortKey="Jang, C" uniqKey="Jang C">C Jang</name></author><author><name sortKey="Choi, Dk" uniqKey="Choi D">DK Choi</name></author><author><name sortKey="Koh, Bi" uniqKey="Koh B">BI Koh</name></author><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kataru, Rp" uniqKey="Kataru R">RP Kataru</name></author><author><name sortKey="Jung, K" uniqKey="Jung K">K Jung</name></author><author><name sortKey="Jang, C" uniqKey="Jang C">C Jang</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Schwendener, Ra" uniqKey="Schwendener R">RA Schwendener</name></author><author><name sortKey="Baik, Je" uniqKey="Baik J">JE Baik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angeli, V" uniqKey="Angeli V">V Angeli</name></author><author><name sortKey="Ginhoux, F" uniqKey="Ginhoux F">F Ginhoux</name></author><author><name sortKey="Llodra, J" uniqKey="Llodra J">J Llodra</name></author><author><name sortKey="Quemeneur, L" uniqKey="Quemeneur L">L Quemeneur</name></author><author><name sortKey="Frenette, Ps" uniqKey="Frenette P">PS Frenette</name></author><author><name sortKey="Skobe, M" uniqKey="Skobe M">M Skobe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zampell, Jc" uniqKey="Zampell J">JC Zampell</name></author><author><name sortKey="Yan, A" uniqKey="Yan A">A Yan</name></author><author><name sortKey="Elhadad, S" uniqKey="Elhadad S">S Elhadad</name></author><author><name sortKey="Avraham, T" uniqKey="Avraham T">T Avraham</name></author><author><name sortKey="Weitman, E" uniqKey="Weitman E">E Weitman</name></author><author><name sortKey="Mehrara, Bj" uniqKey="Mehrara B">BJ Mehrara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zampell, Jc" uniqKey="Zampell J">JC Zampell</name></author><author><name sortKey="Yan, A" uniqKey="Yan A">A Yan</name></author><author><name sortKey="Avraham, T" uniqKey="Avraham T">T Avraham</name></author><author><name sortKey="Andrade, V" uniqKey="Andrade V">V Andrade</name></author><author><name sortKey="Malliaris, S" uniqKey="Malliaris S">S Malliaris</name></author><author><name sortKey="Aschen, S" uniqKey="Aschen S">S Aschen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avraham, T" uniqKey="Avraham T">T Avraham</name></author><author><name sortKey="Zampell, Jc" uniqKey="Zampell J">JC Zampell</name></author><author><name sortKey="Yan, A" uniqKey="Yan A">A Yan</name></author><author><name sortKey="Elhadad, S" uniqKey="Elhadad S">S Elhadad</name></author><author><name sortKey="Weitman, Es" uniqKey="Weitman E">ES Weitman</name></author><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Debnath, J" uniqKey="Debnath J">J Debnath</name></author><author><name sortKey="Muthuswamy, Sk" uniqKey="Muthuswamy S">SK Muthuswamy</name></author><author><name sortKey="Brugge, Js" uniqKey="Brugge J">JS Brugge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liang, Cc" uniqKey="Liang C">CC Liang</name></author><author><name sortKey="Park, Ay" uniqKey="Park A">AY Park</name></author><author><name sortKey="Guan, Jl" uniqKey="Guan J">JL Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cursiefen, C" uniqKey="Cursiefen C">C Cursiefen</name></author><author><name sortKey="Maruyama, K" uniqKey="Maruyama K">K Maruyama</name></author><author><name sortKey="Jackson, Dg" uniqKey="Jackson D">DG Jackson</name></author><author><name sortKey="Streilein, Jw" uniqKey="Streilein J">JW Streilein</name></author><author><name sortKey="Kruse, Fe" uniqKey="Kruse F">FE Kruse</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cao, R" uniqKey="Cao R">R Cao</name></author><author><name sortKey="Lim, S" uniqKey="Lim S">S Lim</name></author><author><name sortKey="Ji, H" uniqKey="Ji H">H Ji</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Honek, J" uniqKey="Honek J">J Honek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rutkowski, Jm" uniqKey="Rutkowski J">JM Rutkowski</name></author><author><name sortKey="Moya, M" uniqKey="Moya M">M Moya</name></author><author><name sortKey="Johannes, J" uniqKey="Johannes J">J Johannes</name></author><author><name sortKey="Goldman, J" uniqKey="Goldman J">J Goldman</name></author><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldman, J" uniqKey="Goldman J">J Goldman</name></author><author><name sortKey="Le, Tx" uniqKey="Le T">TX Le</name></author><author><name sortKey="Skobe, M" uniqKey="Skobe M">M Skobe</name></author><author><name sortKey="Swartz, Ma" uniqKey="Swartz M">MA Swartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shin, K" uniqKey="Shin K">K Shin</name></author><author><name sortKey="Kataru, Rp" uniqKey="Kataru R">RP Kataru</name></author><author><name sortKey="Park, Hj" uniqKey="Park H">HJ Park</name></author><author><name sortKey="Kwon, Bi" uniqKey="Kwon B">BI Kwon</name></author><author><name sortKey="Kim, Tw" uniqKey="Kim T">TW Kim</name></author><author><name sortKey="Hong, Yk" uniqKey="Hong Y">YK Hong</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Garcia Nores, Gabriela D" sort="Garcia Nores, Gabriela D" uniqKey="Garcia Nores G" first="Gabriela D." last="García Nores">Gabriela D. García Nores</name><name sortKey="Gardenier, Jason C" sort="Gardenier, Jason C" uniqKey="Gardenier J" first="Jason C." last="Gardenier">Jason C. Gardenier</name><name sortKey="Ghanta, Swapna" sort="Ghanta, Swapna" uniqKey="Ghanta S" first="Swapna" last="Ghanta">Swapna Ghanta</name><name sortKey="Hespe, Geoffrey E" sort="Hespe, Geoffrey E" uniqKey="Hespe G" first="Geoffrey E." last="Hespe">Geoffrey E. Hespe</name><name sortKey="Kataru, Raghu P" sort="Kataru, Raghu P" uniqKey="Kataru R" first="Raghu P." last="Kataru">Raghu P. Kataru</name><name sortKey="Mehrara, Babak J" sort="Mehrara, Babak J" uniqKey="Mehrara B" first="Babak J." last="Mehrara">Babak J. Mehrara</name><name sortKey="Nitti, Matthew D" sort="Nitti, Matthew D" uniqKey="Nitti M" first="Matthew D." last="Nitti">Matthew D. Nitti</name><name sortKey="Savetsky, Ira L" sort="Savetsky, Ira L" uniqKey="Savetsky I" first="Ira L." last="Savetsky">Ira L. Savetsky</name><name sortKey="Torrisi, Jeremy S" sort="Torrisi, Jeremy S" uniqKey="Torrisi J" first="Jeremy S." last="Torrisi">Jeremy S. Torrisi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001771 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001771 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4454507
|texte= Th2 Cytokines Inhibit Lymphangiogenesis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:26039103" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |